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Oh, it turns out you sometimes have to manually change the sync source to "Internal" as seen here: If the "Locked" indicator on the unit does not show, it won't work.

make sure your audio track's input is set to analogue 1&2, that your track is set to record (obviously), and also make sure you follow the steps that the previous commenter mentioned. Don't use instrument tracks for audio either. Those are meant for midi so that you don't have to bus your midi track to an audio track anymore and so it's all in one track ...

The MBox mini seems to have a mix control knob. Try tweaking the position of the knob to see if the signal you're hearing is routed through the interface directly or if it is already routed through ProTools. If the knob is turned all the way to 'P/B' and you're no longer hearing the guitar, then your ProTools is not configured properly. Have you checked ...

OK, I have at least discovered the cause now, which is some kind of ground loop. I had ordered a replacement power supply for my Dell XPS M1530 laptop as the old one was making funny noises and the cable sheathing was torn. However, it now appears the old power supply (original Dell) earthed the laptop, while the new one doesn't (hence the hum doesn't go ...